Fig. 2: Cryo-EM structure of Ty3 strand-transfer complex bound to TFIIIB transcription factor and tD(GUC)K tRNA gene.
From: Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
a Ribbon representation (front view) of Ty3 retrotransposon strand-transfer complex (STC) bound to TFIIIB transcription factor and the t(GUC)K gene. Four integrase molecules are numbered and coloured in grey, yellow, purple and brown. Brf1, TBP and Bdp1 subunits of TFIIIB are depicted in green, pink and orange, respectively. Template and non-template strands of the tDNA are shown in dark and light blue, respectively. Ty3 long-terminal repeats (LTRs) are highlighted in red shades. b Ty3 retrotransposon model representing as silhouettes the domain architecture of Ty3 integrase subunits (inset). NED N-terminal extended domain, NTD N-terminal domain, CCD catalytic core domain, CTD C-terminal domain, CHD chromodomain.
