Fig. 4: Identification of liver tissue regions with unique transcriptional patterns. | Nature Communications

Fig. 4: Identification of liver tissue regions with unique transcriptional patterns.

From: Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Fig. 4

a Projection of spots including transcriptional patterns of cluster 5 in the UMAP and tissue (Fig. 1b), on the respective part of a histological section of the caudate lobe (left) and spot location in the entire tissue section (right). b Visualization of Vim, Col3a1, Col1a2 and Gsn expression in spots of the same tissue section as in a. c Gene-ontology (GO:BP) enrichment for marker genes present in cluster 5. The Enrichment is given as the negative log10 algorithm of the adjusted p-value (g:SCS correction, Methods) of the differentially expressed marker genes in cluster 5. d Module scores of cluster 5 marker genes (Methods) associated with the two biological processes with the highest enrichment scores: “collagen fibril organization” and “response to cytokine” are visualized on spots across the tissue.

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