Fig. 1: Nucleosides of the queuosine family present in higher vertebrates.
From: Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine
a Queuosine 1 is derived from a 7-deazaguanosine base with a 1(S)-amino-2(R),3(S)-dihydroxycyclopent-4-ene unit attached via a methylene linker to the C7-position of the 7-deazaguanosine. Possible glycosylation sites are depicted in dark blue (allylic hydroxyl group) and light blue (homoallylic hydroxyl group); b Structure of the naturally occurring nucleoside β-homoallyl-galQ 2; c Structure 3 shows the originally proposed structure of manQ, which we revise in this work; d Corrected structure of natural manQ 4 featuring an α-allylic connectivity.
