Fig. 3: CRIg−/− mice are more susceptible to E. faecalis- and ethanol-induced liver disease. | Nature Communications

Fig. 3: CRIg−/− mice are more susceptible to E. faecalis- and ethanol-induced liver disease.

From: CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

Fig. 3

WT, CRIg−/− and CRIg−/−/Tlr2−/− mice were placed on the chronic–binge ethanol diet and gavaged with a cytolytic E. faecalis strain (5 × 108 colony forming units (CFUs)) every third day. a Serum levels of ALT. b Hepatic triglyceride content. c Representative oil red O-stained liver sections. d Hepatic levels of mRNAs encoding inflammatory cytokines and chemokines IL1B, CXCL1, and CXCL2. e Serum levels of ethanol in ethanol-fed mice. f Hepatic levels of Adh1 and Cyp2e1 mRNAs. Scale bar = 100 μm. Results are expressed as mean ± s.e.m. (a, b, d–f). P values among groups of mice fed with control diet or ethanol diet are determined by one-way ANOVA with Tukey´s post-hoc test (a, b, d–f). *P < 0.05, **P < 0.01, ***P < 0.001.

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