Table 2 Transcription factor binding motif enrichment for GSK-J4 target genes (top 15).

From: KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

 

Gene sets

NES

NOM p-val

FDR q-val

1

KRCTCNNNNMANAGC_UNKNOWN

2.43

0

0

2

SGCGSSAAA_V$E2F1DP2_01

1.48

0.003

0.253

3

V$E2F_01

1.42

0.037

0.31

4

V$E2F_Q3

1.39

0.012

0.325

5

TTTNNANAGCYR_UNKNOWN

1.39

0.023

0.262

6

V$E2F_Q6

1.36

0.012

0.274

7

V$E2F1_Q3

1.33

0.015

0.308

8

V$E2F4DP1_01

1.32

0.018

0.301

9

V$E2F1_Q6

1.32

0.02

0.269

10

V$E2F_Q4

1.31

0.013

0.273

11

RGTTAMWNATT_V$HNF1_01

1.31

0.071

0.25

12

V$E2F1DP2_01

1.29

0.027

0.268

13

V$E2F_02

1.28

0.028

0.266

14

V$E2F1_Q6_01

1.28

0.042

0.255

15

V$E2F1DP1_01

1.28

0.037

0.246

  1. Gene set enrichment scores analyzed by GSEA program. NES normalized enrichment score, NOM p-val nominal p value, FDR false discovery rate. p Value calculated by one-sided Fisher’s exact test. The FDR is calculated by comparing the distribution of normalized enrichment scores from many different genesets.
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