Fig. 2: Previous studies in asymmetric IEDHDA with neutral alkene partners and our approach.

a Previous studies on intermolecular asymmetric IEDHDA reactions. b Previous studies on intramolecular asymmetric IEDHDA reactions. c Our approach to asymmetric intramolecular IEDHDA via dual hydrogen bonding interaction. d Access to tricyclic tetrahydropyran derivatives by chiral phosphoric acid catalyzed intramolecular IEDHDA reaction. .