Fig. 2: Fibroblast heterogeneity in ESCC. | Nature Communications

Fig. 2: Fibroblast heterogeneity in ESCC.

From: Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment

Fig. 2

A UMAP visualization of the clustering of 12,126 fibroblast cells from all 22 nonmalignant and tumor samples. B The fraction of each fibroblast subset in nonmalignant and tumor samples (left), and in each of the 11 patients (right, an analysis restricted within tumor samples). C Dotplot showing the expression of top 10 most variable genes across each fibroblast subset. D Violin plots of the expression of representative ECM (extracellular matrix) genes and ACTA2 in each fibroblast subset. E Enrichment of GO (gene ontology) terms of each fibroblast subset (FDR-adjusted P < 0.001, Fisher exact test with multiple comparisons using topGO). Source data are provided as a Source Data file.

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