Fig. 5: Myeloid and T cell landscapes of ESCC. | Nature Communications

Fig. 5: Myeloid and T cell landscapes of ESCC.

From: Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment

Fig. 5

A UMAP visualization of 17,923 immune cells extracted in silico from all 22 nonmalignant and tumor samples. B Dotplot showing the average expression of representative marker genes and percentages of expressed cells in each immune subset. C Violin plots showing the expression of selected genes for CD4+ T cell subsets or (D) CD8+ T cell subsets across nonmalignant (green) and tumor (blue) samples. E Volcano plot of the differentially expressed genes between the two CD8+ T cell subsets (CD8_1 and CD8_2 specific genes are highlighted in blue and red, respectively). F A circos plot showing the higher overall number of significant interacting pairs estimated by CellPhoneDB (P < 0.05) between myeloid and T cell subsets in tumor (blue) and nonmalignant (green) samples. G Estimated mean interaction scores for specific interactions (PDCD1-CD274, CTLA4-CD80/CD86) from indicated cell types in tumor and nonmalignant samples. N, nonmalignant; T, tumor. Source data are provided as a Source Data file.

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