Fig. 5: Neuronal adhesion molecules NRXN1 and NLGN1 are expressed in the epithelial, endothelial, immune and neuronal cells in prostate cancer.
From: Epigenetic loss of heterogeneity from low to high grade localized prostate tumours
Protein expression of NLGN1 (yellow) and NRXN1 (red) in tumours with Gleason pattern 3, characterized by well-formed discrete glands with wide lumens (Sample_8) (a) and Gleason pattern 4, characterized by irregular glands with cribriform and branching architecture (Sample_4) (b). Supplementary Figure 10 shows H&E images and ROIs for each sample. Scale bars (white line) show 200 pixels. c Expression of NRXN1 and NLGN1 across different cell types from three tissue sections acquired from high-risk patients with Gleason pattern 4 prostate tumours in our cohort. X-axis shows cell types and Y-axis shows the total number of segmented cells (top) or percentage population of cells positive for that marker (bottom). NRXN1 expressing cells are shown in blue and NLGN1 in green. Cells that express both proteins are shown in purple and cells that do not express either are marked with pink. d Expression of NRXN1 and NLGN1 across different cell types from five tissue sections acquired from low-risk patients with Gleason pattern 3 tumours in our cohort. X-axis shows cell types and Y-axis shows the total number of segmented cells (top) or percentage population of cells positive for that marker (bottom). NRXN1 expressing cells are shown in blue and NLGN1 in green. Cells that express both proteins are shown in purple and cells that do not express either are shown in pink.
