Fig. 5: Mechanism of action of anti-BMP1.3 antibody. | Nature Communications

Fig. 5: Mechanism of action of anti-BMP1.3 antibody.

From: Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction

Fig. 5

The anti-BMP1.3 monoclonal antibody blocks the enzymatic activity of BMP1.3, exerting pleiotropic therapeutic effects after MI. On the one hand, BMP1.3 inhibition reduces collagen maturation. On the other hand, it results in TGFβ pathway inhibition, which in turns reduces myofibroblast activation, Lox expression and collagen cross-linking and increases the expression of cardioprotective BMPs.

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