Table 1 Risk factors for time to clearance of incident HR-HPV infections.

From: molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history

 

Model 1: molBV

Model 2: Sustained IL-1β/IP-10 and molBV

Model 3: Parsimonious

Variable

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

IL-1β/IP-10: Sustained-high ref)

—

—

—

—

—

—

—

—

—

IL-1β/IP-10: Sustained-low

—

—

—

1.87

1.08–3.20

0.027

1.86

1.19–2.90

0.006

Age

1.07

1.00–1.14

0.063

1.05

0.97–1.10

0.21

1.05

0.98–1.10

0.16

Smoking

0.87

0.66–1.14

0.32

0.90

0.64–1.30

0.53

0.90

0.64–1.30

0.53

HPV16 Status

1.04

0.73–1.49

0.82

0.97

0.61–1.60

0.91

0.98

0.61–1.60

0.91

molBV: Sustained-low (ref)

—

—

—

—

—

—

—

—

—

molBV: Became-high

0.84

0.51–1.38

0.49

0.97

0.52–1.80

0.94

—

—

—

molBV: Became-low

0.55

0.31–0.97

0.039

0.38

0.15–1.00

0.051

—

—

—

molBV: Sustained-high

0.85

0.56–1.28

0.43

 1.05

0.57–1.90

0.88

—

—

—

  1. This table shows the adjusted cox-proportional hazard models for the outcome of clearance of incident HR-HPV infections. In Model 1, categorical molBV state combinations from Visit 1 and Visit 2 are presented with adjustment for age, smoking status and HPV16 (at V2). In Model 2, sustained IL-1β/IP-10 levels are modeled with the inclusion of the molecular BV categories. For these analyses, both IL-1β/IP-10 and molBV were dichotomized as either high (above the median) or low (below the median) at each visit. Model 3 shows the adjusted hazard ratio of IL-1B/IP-10 levels without molBV in the model. Bolded values indicate statistically significant results (p-value < 0.05). HR, hazard ratio; 95% CI, 95% confidence interval. HR > 1.0 represent factors associated with a shorter time to clearance; whereas, HR < 1.0 are associated with increased time to clearance.
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