Table 2 Risk factors for progression to CIN2+.

From: molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history

Variable

Model 1: molBV

Model 2: IL-1β/IP-10 & molBV

Model 3: TNF-α/MIP-1β & molBV

Model 4: IL-1β/IP-10 and TNF-α/MIP-1β & molBV

Model 5: Parsimonious

 

OR

95% CI

P value

OR

95% CI

P value

OR

95% CI

P value

OR

95% CI

P value

OR

95% CI

P value

IL-1β/IP-10

—

—

—

1.15

0.92–1.46

0.22

—

—

—

1.04

0.80–1.34

0.73

—

—

—

TNF-α/MIP-1β

—

—

—

—

—

—

2.71

1.46–5.61

0.002

2.65

1.39–5.58

0.004

2.81

1.62–5.42

0.0007

molBV

1.24

1.02–1.55

0.039

1.16

0.92–1.48

0.23

1.03

0.81–1.31

0.82

1.01

0.78–1.32

0.92

—

—

—

Age

0.92

0.92–0.77

0.33

0.92

0.77–1.10

0.40

0.86

0.71–1.03

0.10

0.86

0.71–1.04

0.12

0.86

0.71–1.02

0.08

Smoking

1.47

0.66–3.23

0.33

1.51

0.67–3.36

0.31

1.37

0.59–3.14

0.54

1.39

0.59–3.21

0.53

1.35

0.59–3.05

0.56

HPV16 Status

1.26

0.48–3.29

0.63

1.27

0.48–3.35

0.67

1.62

0.58–4.69

0.44

1.60

0.57–4.65

0.45

1.63

0.58–4.70

0.44

  1. This table shows the generalized linear models for the outcome of progression to CIN2+. Two inflammatory signatures were evaluated. Levels of IL-1β/IP-10 and TNF-α/MIP-1β were dichotomized into high or low based on above or below the median, respectively. Progression to CIN2+ was observed after the collected V2 sample for all subjects (average of 2.68 years after V2 sample collection). Variables measured at V2 were used for the analysis. Bolded values indicate statistically significant results (p-value < 0.05).
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