Fig. 1: Association of ADMA levels and the -394 4N del/ins polymorphism of Ddah1 with bone mineral density in a large Chinese population-based study. | Nature Communications

Fig. 1: Association of ADMA levels and the -394 4N del/ins polymorphism of Ddah1 with bone mineral density in a large Chinese population-based study.

From: Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Fig. 1

a qPCR of Ddah1 mRNA in hemocytes from patients with -394 del/del, -394 del/ins and -394 ins/ins Ddah1 genotypes. **p < 0.01. del/del, n = 19. del/ins, n = 12. ins/ins, n = 8. Data are represented as mean values ± SD. The data were analyzed by an unpaired two-tailed Student’s t test in all panels. b Results from LC-MS assay for ADMA concentrations of the serum samples from -394 del/del, -394 del/ins and -394 ins/ins patients. **p < 0.01. del/del, n = 420. del/ins, n = 126. ins/ins, n = 24. Data are represented as mean values ± SD. The data were analyzed by an unpaired two-tailed Student’s t test in all panels. c Results from LC-MS assay for ADMA concentrations of the serum samples from control, osteopenia and osteoporosis participants. **p < 0.01. ***p < 0.005. control, n = 190. osteopenia, n = 117. osteoporosis, n = 263. Data are represented as mean values ± SD. The data were analyzed by an unpaired two-tailed Student’s t test in all panels.

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