Fig. 2: The TCPTP C-terminal tail autoinhibits TCPTP. | Nature Communications

Fig. 2: The TCPTP C-terminal tail autoinhibits TCPTP.

From: The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1

Fig. 2

a Comparison of the catalytic activity between TCPTP with TCPTPCAT (residues 1–314) vs pEGFR peptide-1, derived from the EGFR cytoplasmic tail. b Comparison of the catalytic activity between TCPTP with TCPTPCAT (residues 1–314) vs DiFMUP. Data in (a) and (b) are presented as the mean of nine independent reactions (n = 9; mean ± SE). c Sequence alignment of TCPTP and PTP1B. Identical residues are highlighted in orange, lysines are underlined; residues exhibiting CSP due to the TCPTPTail are boxed with corresponding loops indicated (colored as in Figs. 3 and 4); secondary structural elements are shown above the sequence. Source data are provided as a Source Data file.

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