Fig. 5: Network modules with infection-specific lncRNAs and GO term enrichments related to fungal virulence.

Module “darkred” of C. albicans (at the top), showing nodes with WGCNA weight > 0.01 and degree ≥ 1, for better visibility. Module “coral1” of C. tropicalis (at the bottom), showing nodes with WGCNA weight >0.1 and degree >3. Circular nodes represent protein coding genes; diamond-shape nodes represent lncRNAs; Nodes highlighted with colored ovals correspond to genes with significant GO term enrichments related to fungal pathogenicity. Edges represent significant correlations as estimated by WGCNA; colors of nodes correspond to the module names assigned by WGCNA software (“darkred” and “coral1” for C. albicans and C. tropicalis, respectively); nodes with blue borders represent infection-specific genes (infection specific protein-coding genes are obtained from⁶⁵); Identifiers of infection-specific lncRNAs are mentioned at the top of corresponding nodes. Nodes which are not assigned to virulence-related GO terms are positioned according to Prefuse Force directed layout.