Fig. 3: Frequencies of IL-2 and IFNγ-secreting but not IL-4 secreting cells correlate with virus-neutralization activity in SARS-CoV-2 convalescents. | Nature Communications

Fig. 3: Frequencies of IL-2 and IFNγ-secreting but not IL-4 secreting cells correlate with virus-neutralization activity in SARS-CoV-2 convalescents.

From: Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Fig. 3

a Frequencies of spike-reactive IL-4- or IL-5-secreting cells in convalescents (red, n = 23) or naïve individuals (blue, n = 6). b, c Correlation of frequencies of S1- or S2-reactive IFNγ-, IL-2-, TNF-, or IL-4-secreting cells with virus-neutralization activity or anti-SARS-CoV-2 IgG in convalescents. Statistical analyses by two-sided Mann–Whitney test (a), Spearman correlation and linear regression (b, c); rs denotes Spearman correlation coefficient; n.s. denotes not significant; ****p < 0.0001.

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