Fig. 2: T cell activation. | Nature Communications

Fig. 2: T cell activation.

From: Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

Fig. 2

J76 TPR cell line with transgenic TCR were co-cultivated with K562-A*02 cell line loaded with various concentrations of the cognate peptide, mutant peptide, or the homologous peptides from the endemic coronaviruses (n = 3 independent replicates). T cell activation was measured by eGFP expression regulated by the NFAT promoter. Plotted are the mean share of eGFP+ cells and SD. Studied receptor is indicated above each graph. IC50 values are shown for the cognate peptide (green) and mutant peptide (violet).

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