Fig. 9: Schematic illustration of the mechanisms of Acp5 in fibroblasts. | Nature Communications

Fig. 9: Schematic illustration of the mechanisms of Acp5 in fibroblasts.

From: Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling

Fig. 9

Acp5 is upregulated by TGF-β1 in a TGFβR1/Smad3 depend manner, and then Acp5 specially binds to p-β-catenin and dephosphorylate the sites of Ser33 and Thr41, by which it resists the degradation of β-catenin and enhanced β-catenin signaling in the nuclear to promote the differentiation, proliferation and migration of fibroblasts.

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