Fig. 5: Astrocytic Nrf2 reduces phospho-tau accumulation and neurodegeneration. | Nature Communications

Fig. 5: Astrocytic Nrf2 reduces phospho-tau accumulation and neurodegeneration.

From: Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Fig. 5

A Schematic illustrating the crossing of MAPTP301S and GFAP-Nrf2 mice. B, C NeuN staining of upper cortical layers of mice at early-stage disease. Mean ± SEM shown. F (2, 21) = 28.83, p = 9.5E−7 (1-way ANOVA); * Post-hoc (Bonferroni) p values: 3.8E−07, 0.0028. N = 6 WT, 9 MAPTP301S and 9 MAPTP301S_X_GFAP-Nrf2 mice. Example pictures shown in (C); scale bar 20 µm. D, E Cortical slices were subject to AT8 immunofluorescent staining, and positive cells counted. Mean ± SEM shown from n = 10 MAPTP301S and n = 7 MAPTP301S_X_GFAP-Nrf2 mice. Where more than one slice was analysed per mouse, and average was taken to provide a single data point per mouse. Main genotype effect: F (1, 60) = 26.54, p = 3.02E−6 (two-way ANOVA). Post-hoc (Bonferroni) p values: 0.010, 0.0017. D Shows example pictures, scale bar 100 µm.

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