Table 1 Description of the ten independent genome-wide significant variants identified in our GWAS).

From: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis

Cytoband

Best trait

Independent SNP rsID

#SNPs in Credible set 99% (95%)

Candidate gene (kb)

Effect allele/ other allele

Weighted effect allele freq

I2 (%)

(Cond.) Beta

(Cond.) p-val

Exp. Var (%)

2p21

tSito

rs4299376

3 (3)

ABCG8 (0)

T/G

0.68

0

−0.133

9.5 × 10−74

3.27

2p21

tSito

rs11887534

7 (5)

ABCG8 (0)

C/G

0.065

0

−0.178

8.3 × 10−39

1.71

2p21

tSito

rs7598542

16 (7)

ABCG8 (0)

C/G

0.21

52

−0.052

5.1 × 10−10

0.39

2p21

tSito

rs78451356

12 (11)

ABCG5 (5.9)

G/T

0.17

9.4

0.069

1.1 × 10−14

0.61

5q13.3

tBras/fLano

rs12916

37 (21)

HMGCR (0)

C/T

0.42

0

−0.059

2.3 × 10−11

0.51

7p13

tCamp

rs217385

24 (22)

NPC1L1 (21)

T/G

0.43

0

−0.041

6.3 × 10−15

0.62

9q34.2

tCamp

rs2519093

38 (23)

ABO (0)

T/C

0.22

0

0.045

1.6 × 10−12

0.51

10q25.3

tSito

rs2286779

4 (4)

PNLIPRP2 (0)

C/G

0.53

15

0.054

1.9 × 10−15

0.64

12q24.31

tSito

rs10846744

5 (5)

SCARB1 (0)

C/G

0.17

68

0.063

2.9 × 10−12

0.50

19q13.32

eStig

rs7412

1 (1)

APOE (0)

T/C

0.088

0

−0.073

1.9 × 10−14

0.83

  1. For the locus 2p21, four independent variants were discovered by Cojo-Select analysis. For the other loci, only a single independent variant was found. For each variant, we present cytoband, best associated trait at this locus, rsID and corresponding statistics (of fixed effect meta-analysis of gene-dose effects). For the 2p21 variants, conditional effect estimates and p-values are shown. The sizes of the 99%, respectively 95% credible sets are also provided. Corresponding variants are annotated in Supplementary Data S8. Annotations are in accordance with genome-build GRCh37. Trait abbreviations are explained in Supplementary Data S18.
Back to article page