Fig. 3: Effect of TFO or D,D-POC1 on the mechanical stability of the DNA duplex or the chimeric POC duplex D,D-POC(2 + 3).

Schematic diagrams, typical force-extension curves and corresponding force histograms of (A) DNA duplex control, (B) D,D-POC(2 + 3), (C) L,D-POC(2 + 3), (D) DNA triplex control, (E) D,D-POC(1 + 2 + 3). TFO = 3′-TTTTCCCTCTCTCT. Note: red and black traces in a force-extension curve represent stretching and relaxing events, respectively. N and n depict total numbers of features and distinct molecules, respectively.