Fig. 6: The stability of POC triple helices is influenced by the helical sense mismatch/match and the templated binding effect.

D-DNA triplex is marked in cyan rectangle, L-peptide coiled-coil in orange ellipse and D-peptide coiled-coil in purple ellipse. M and P stand for left-handed and right-handed inter-strand helical senses, respectively. (Top: The clash symbol means the helical sense mismatch state, which may result in unfavourable energy cost and thus is marked in a red-cross. The no clash symbol represents the helical sense match state, which should not influence the stability and thus is marked in a green check).