Fig. 8: BCR data analysis, part 1.

a Number of cells (closed-bars) and number of clones (open-bars) in patients colored based on the treatment and status of the disease. b Fractional abundance of memory B cells, naive B cells, and plasma cells in each sample. c Fractional abundance of isotypes (IGHM/D/G/A) in each sample. d–f CDR3 amino acid length (x axis) and mutation frequency (y axis) for each cell type (memory B cell and plasma cell columns) and isotype (IGHG and IGHM rows) of stable patients with no treatment, progressive patients under treatment, and stable patients under treatment. Colors indicate different samples. Vertical dashed line represents 15 amino acid CDR3 length reference point and horizontal line represents 5% mutation frequency reference point. Points with larger size belong to the expanded clones. g CDR3 amino acid usage at time-point B relative to A for patients grouped based on the treatment and status of the disease. h Cell type fractional abundance of expanded clones in each sample. Labels in each bar represent the number of expanded clones (top) and number of cells (bottom). i Isotype fractional abundance of expanded clones in each sample. Labels as described in h. Source data are provided as a Source Data file.