Fig. 3: Homeodomain and zinc finger proteins are enriched at R-loops.
From: Proximity labeling identifies a repertoire of site-specific R-loop modulators
a Venn diagram showing overlap between enriched proteins in RHΔ-TurboID, S9.6 IP, and DNA:RNA hybrid IP. Total number of significantly enriched proteins (adjusted p value < 0.05), and the numbers shared between the three methods are indicated. b Distribution of R-loop interactors from RHΔ-TurboID, S9.6 IP, and DNA:RNA hybrid IP based on molecular functions. c Top 5 most significantly enriched domains in RHΔ-TurboID and S9.6 IP. Adjusted p-values calculated by Enrichr using hypergeometric test with Benjamini–Hochberg adjustment for multiple comparisons. d Volcano plot showing log2 fold changes in protein intensities on the x-axis and −log10 adjusted p-values (Student’s two-sided t-test with Benjamini–Hochberg adjustment for multiple comparisons) on the y-axis in RHΔ-TurboID. Significantly enriched proteins in blue (p < 0.05) and non-significant in black. Homeodomain proteins are highlighted in red; components of the Mediator complex are highlighted in yellow. e Volcano plot showing log2 fold changes in protein intensities on the x-axis and −log10 adjusted p-values (Student’s two-sided t-test with Benjamini–Hochberg adjustment for multiple comparisons) on the y-axis in RHΔ-TurboID. Significantly enriched proteins (blue, p < 0.05) and non-significant in black. Zinc finger containing proteins are highlighted in red. f Volcano plot showing log2 fold changes in protein intensities on the x-axis and −log10 adjusted p-values (Student’s two-sided t-test with Benjamini–Hochberg adjustment for multiple comparisons) on the y-axis in S9.6 IP. Significantly enriched proteins (blue, p < 0.05) and non-significant in black. Zinc finger containing proteins are highlighted in red.
