Fig. 6: Regulation of hepatic FXR-CYP7A pathway by H2S. | Nature Communications

Fig. 6: Regulation of hepatic FXR-CYP7A pathway by H2S.

From: Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

Fig. 6

A Serum levels of H2S in co-housing mice (n = 5 mice/group). Data are expressed as mean ± SEM. Statistics was performed by two-sided ANOVA with LSD post hoc analysis between groups. “C”: C57BL/6J, “A”: AKR/J, “coH.C”: C57BL/6J co-housing with AKR/J and “coH.A”: AKR/J co-housing with C57BL/6J. B GYY4137 induced FXR protein and inhibited CYP7A1 protein expression in mouse liver (n = 3 mice/group). Data are expressed as mean ± SEM. Statistics was performed by a two-sided t test. C Regulation of FXR and CYP7A1 by GYY4137 in mouse hepatocytes Hepa1-6 (3 independent experiments/treatment). Data are expressed as mean ± SEM. Statistics was performed by two-sided ANOVA with LSD post hoc analysis between groups. D Regulation of FXR and CYP7A1 by GYY4137 in human hepatoma cells HuH7 (three independent experiments/treatment). Data are expressed as mean ± SEM. Statistics was performed by two-sided ANOVA with LSD post hoc analysis between groups. Source data are provided as a Source data file.

Back to article page