Fig. 7: Species of Desulfovibro promoted gallstone formation in mice. | Nature Communications

Fig. 7: Species of Desulfovibro promoted gallstone formation in mice.

From: Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

Fig. 7

A Incidence of gallstone (n = 10 mice/group). B Serum cholesterol in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) (n = 10 mice/group). Data are expressed as mean ± SEM. Statistics was performed by a two-sided t test and C hepatic cholesterol levels (n = 10 mice/group). Data are expressed as mean ± SEM. Statistics was performed by a two-sided t test. D Quantitative real-time PCR analysis of gene expression levels in hepatic cholesterol and bile acid metabolism (n = 10 mice/group). Data are expressed as mean ± SEM. Statistics was performed by a two-sided t test. E Lipid composition in hepatic bile collected by common bile duct cannulation in each group (n = 5 mice/group). Data are expressed as mean ± SEM. Statistics was performed by t test. “Desulfo”: antibiotics-pre-treated C57BL/6J mice receiving Desulfovibrio species. “Ctrl”: antibiotics-pre-treated control C57BL/6J mice. Source data are provided as a Source data file.

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