Fig. 2: Interactions of oxyntomodulin and exendin-4 peptides within the TMD binding cavity of the GLP-1R.
From: Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
a GLP-1R (dark pink) and oxyntomodulin peptide (pale yellow). b GLP-1R (pale green) and exendin-4 (purple). For each binding site two views are depicted for clarity; Left, side view of the TM bundle viewed from the upper portion of TM4/TM5 where TM4-ECL2-TM5 have been removed; Right; side view of the TM bundle viewed from the upper portion of TM6/TM7 where TM6-ECL3-TM7 has been removed. Dashed lines depict hydrogen bonds as determined using default settings in UCSF chimera. Superscript numbering for receptor residues refers to the generic Wootten et al. class B1 numbering system40.
