Fig. 4: Heat maps depicting the 3D representation of the effect of alanine mutation of residues within the TMD peptide-binding cavity on affinity and signalling.
From: Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Models of the peptide bound GLP-1Rs showing residues (in space fill) that altered affinity (top) or signalling (bottom) of GLP-1, exendin-4, oxyntomodulin and exendin-P5 relative to the wild type receptor when mutated. These are coloured depending on their level of effect highlighted in the colour key. TM domains are labelled on the GLP-1-bound model depicting affinity changes, with the same receptor views used for the remaining models.
