Fig. 5: Correlation plots of the changes in peptide affinity and efficacy for TMD mutations relative to the wildtype receptor.
From: Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
a GLP-1 vs. exendin-4; b GLP-1 vs. oxyntomodulin; c GLP-1 vs. Exendin-P5; d Exendin-P5 vs. Oxyntomodulin. Data were fit by linear regression and Pearson correlations (r) were determined and squared (r2), and the P value was calculated using a two-tailed critical t value analysis in Prism 9. The line of regression and 99% confidence intervals are displayed. Mutations are coloured relative to the receptor TM or ECL that they are located as indicated in the legend. Mutant receptors that fall outside of the 99% confidence intervals are labelled. Source data are provided in the Source Data file.
