Fig. 8: Interaction of Gs with the GLP-1R in the presence of different peptide agonists.
From: Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
a Superimposition of GLP-1R:Gs structures bound with GLP-1 (PDB – 6X18, blue), exendin-4 (pale green), oxyntomodulin (dark pink) and exendin-P5 (pale orange) (PDB - 6B3J), viewing the GLP-1R interface. b Contact differences between the four complexes plotted on the receptor (top) and Gs (bottom) surface determined from MD simulations. The first column shows the contacts between GLP-1R (top) and Gs (bottom) during the MD simulations in the presence of GLP-1, with no contacts in cyan and increasing contacts heat mapped from white to dark pink. The other three columns report the contact differences (relative to GLP-1) for each residue of the GLP-1R and Gs during the MD performed in the presence of the other agonists with blue indicating fewer contacts, white similar contacts, and red enhanced contacts.
