Fig. 7: Results for the lipidomic profiling in Phase III and investigating the influence of cancer stage, age, and diabetes mellitus.
From: Lipidomic profiling of human serum enables detection of pancreatic cancer
a ROC curves for males (M) and females (F) in training (Tr.) and validation (Va.) sets. Box plots of lipid molar concentrations normalized to the NIST reference material for: b SM 41:1 and c Cer 41:1. Only samples with known tumor (T) stage classification were included, where early stage (T1 and T2, 24 males and 30 females) and late stages (T3 and T4, 174 males and 176 females) are summarized and compared to samples of healthy controls (128 males and 134 females) and pancreatitis patients (13 males and 9 females). Comparison of age intervals for control (blue) and cancer (red) samples (d) SM 41:1 and e LPC 18:2. Box plot investigating the influence of diabetes (f) SM 41:1. In each box plot, the centerline represents the median, the bounds represent the 1st and 3rd quartile and whiskers span 1.5 fold inter-quartile range from the median. Comparison of the ROC curves for the samples investigated in Phase III for both genders (g) red - CA 19-9, blue - lipidomics, green - combination of CA 19-9 and lipidomics, and purple - CancerSeek32. h Sensitivity (red) and specificity (blue) for CA 19-9, lipidomics, combination of CA 19-9 and lipidomics, and CancerSeek. Source data are provided as a Source Data file.
