Fig. 4: CPT1 genetic knockdown reduces the secretion of oxylipins.
From: Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
RAW cells expressing either the non-silencing (RAWnonsil) or Cpt1a knockdown siRNA (RAWCpt1aKD) were treated with LPS (100 ng/ml) for 24 h and secretion of PGs, 17,18-diHETE, or monohydroxy oxylipins were measured using LC/MS/MS as in Methods (n = 6, mean ± SEM, separate wells of cells). Student’s t-test, two-tailed. Where no bar is shown no significant difference was seen.
