Fig. 1: IMPC genomic somatic mutation landscape in 17 freshly frozen IMPC tumor-normal tissue pairs. | Nature Communications

Fig. 1: IMPC genomic somatic mutation landscape in 17 freshly frozen IMPC tumor-normal tissue pairs.

From: Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Fig. 1

a Non-silent somatic mutation patterns and frequencies of the most highly mutated genes (present in at least 3 samples: TP53, CDC27, CELSR2, CEP192, KIF26A, RYR2, TAF4, TPBGL, and known breast cancer-related genes PIK3CA, AKT1, MAP3K1, FOXA1, GATA3, NCOR1, PTEN, PTPRD, and RUNX1; known breast cancer-related genes MAP2K4, MLL3, CDH1, PIK3R1, CBFB, TBX3, CTCF, SF3B1, CDKN1B, RB1, AFF2, NF1, and PTPN22 that are not shown in the figure did not contain mutations). The percentages on the left show the frequencies of gene mutation, and the bars on the top and right represent the number of different mutations in each sample and the sample number in each gene, respectively. b The same non-silent somatic gene mutations as shown in a with patterns and frequencies for TCGA breast cancer dataset. c The same non-silent somatic gene mutations as shown in a with patterns and frequencies for TCGA luminal B breast cancer dataset.

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