Fig. 3: Comparison of genomic CNVs in IMPC samples at the level of multiple-cell clusters between pure and mixed IMPC-IDC. | Nature Communications

Fig. 3: Comparison of genomic CNVs in IMPC samples at the level of multiple-cell clusters between pure and mixed IMPC-IDC.

From: Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Fig. 3

a Genomic CNV landscape in the paired IMPC and IDC components of 14 mixed IMPC-IDC samples. Each row represents a sample; each column represents a genetic locus. The percentages on the left show the genomic instability of each sample across all chromosomal regions, and the bars on the right and top represent the number of different mutations in each sample and the frequency of each genetic locus in the sample, respectively. b–d Venn diagrams reflecting common and unique genes with copy-number aberrations in pure IMPC and mixed IMPC-IDC samples (b), in IMPC and IDC components of primary tumors (c), and in IMPC and IDC components of lymph node metastatic loci (d). Common and unique genes with CNVs are labeled in each category. T primary tumor, L lymph node. e CNV spectrum of the IMPC and IDC components in mixed IMPC-IDC samples. The frequency of each site was determined by calculating the number of losses or gains in the IMPC and IDC components. The −log10 unadjusted P values are shown for comparison, and significantly different CNV genes are labeled with long arrows. The statistic test is a two-sample unequal variance [heteroscedastic] t test, two-sided.

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