Fig. 4: Copy-number evolutionary relationship between the IMPC and IDC components in mixed IMPC-IDC. | Nature Communications

Fig. 4: Copy-number evolutionary relationship between the IMPC and IDC components in mixed IMPC-IDC.

From: Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Fig. 4

a Clonal phylogeny in patient P23. Evolutionary relationships between clones were captured by determining the inheritance of direct genomic instability events in different clones. The branching time of the different cell types during the evolutionary process and the respective characteristic driving genes are labeled. T primary tumor, L lymph node. b The overlap of CNV genes between the primary IMPC and primary IDC components. Venn diagram showing the distribution of genes with CNVs from the primary tumor. The numbers and percentages of genes in each classification are presented. c Pathway analysis of 64 primary IMPC-specific genes. The horizontal axis indicates the significance of the enrichment; the vertical axis indicates the enriched pathways. The well-adopted hypergeometric test and Benjamini–Hochberg P value correction algorithm to identify all ontology terms that contain a significantly greater number of genes in common with an input list than expected by chance. d Similar to b, but an analysis of lymph node metastatic lesions. e Similar to c, but an analysis of lymph node metastatic lesions.

Back to article page