Fig. 2: Kinetic characterization of selected antibodies. | Nature Communications

Fig. 2: Kinetic characterization of selected antibodies.

From: A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

Fig. 2

a Measured affinities and avidities of the selected antibodies (IgGs) against SARS-CoV-2 RBD and trimer respectively. Data represent the average of duplicates of independent affinity measurements for each of the tested antibodies (n = 32) +/− SD. b Isoaffinity plot of the antibodies against RBD (circle) and trimer (triangle) plotting off-rate (s−1) against on-rate (M−1s−1). Data represent the average of duplicates of independent affinity measurements for each of the tested antibodies (n = 32). c Affinity histogram ranked on RBD affinities plotted with corresponding trimer avidities. Data represent average of duplicates of independent affinity measurements for each of the tested antibodies (n = 32) +/− SD. d Ratio of the trimer avidity values divided by the RBD affinity. Source data are provided as a Source Data File.

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