Fig. 5: Comparison of selected SARS-CoV-2 spike antibodies to the published record.

a For each of the individual publications (see introduction) the IgG, Fab, or scFv-Fc with the highest affinity for the RBD is indicated (derived either from recombinant naïve antibody libraries “Library derived Abs” or from immunized animals or recovered Covid19 patients “Immune source Abs”), together with the affinities of 181 antibodies in the CoVIC Ab database recognzing the RBD (“CoVIC Abs”). For the antibodies selected here (“Selected Abs”), the ten IgGs with the highest affinities for the RBD are indicated. For three of the naïve library derived antibodies we showed the reported values and those obtained here (“Meas. Affinity”). b For each of the individual publications the IgGs with the lowest IC₅₀’s obtained using pseudovirus are indicated, while for the CoVIC database the IC₅₀’s of 306 reported antibodies are indicated For the antibodies selected here, the 10 IgGs with the lowest pseudovirus IC₅₀s are indicated. c For each of the individual publications the IgGs with the lowest IC₅₀’s obtained using live virus are indicated, while for the CoVIC database the IC₅₀’s of 288 antibodies assessed by UTMB are indicated (76 antibodies had IC₅₀’s > 25 µg/ml and are not included). For the antibodies selected here, the ten IgGs with the lowest livevirus IC₅₀s are shown. For the publications as well as the antibodies selected here, the top antibody in each individual category is not necessarily the same antibody across all categories (e.g., a high-affinity antibody with poor IC₅₀’s is reported in 5a, but not 5b or 5c). Furthermore, affinity, PSV, and live virus IC₅₀s were not measured in all publications, so only the best measurements in each category that were reported are indicated. Source data are provided as a Source Data File.