Fig. 5: Interaction of BRCA1 and 53BP1 in the tolerance to cytotoxic agents. | Nature Communications

Fig. 5: Interaction of BRCA1 and 53BP1 in the tolerance to cytotoxic agents.

From: BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Fig. 5

a–f Cytotoxicity measurements on DT40 cell lines of the indicated genotypes using drugs named above each panel. Results are shown as mean and SEM of relative IC50 concentrations compared to the WT cell lines, individual values derived from n = 3 independent experiments are indicated. The mean IC50 value of the WT cell line is displayed on each panel. Source data are provided as a Source Data file.

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