Fig. 4: Comparing the rate of age-related changes in DNA methylation levels of NMR-, mouse- and human blood clock CpG sites.

a Mean methylation level of CpG sites that decrease and increase methylation with age in the NMR blood clock. Linear regression and standard deviation are indicated by dashed lines and pale coloring around it. b Mean methylation level of CpG sites that decrease and increase methylation with age in the Petkovich et al. mouse blood clock²⁰. Quadratic regression and standard deviation are indicated by dashed curves and pale coloring around it. c Mean methylation level of CpG sites that decrease and increase methylation with age in the Hannum human blood clock¹⁷. Linear regression and standard deviation are indicated by dashed lines and pale coloring around it. d Mean methylation level of decreasing CpG sites of the three clocks shown on the same age scale (left panel). The same is shown for increasing CpG sites (right panel). Standard deviation is indicated by pale coloring around the mean. e Mean methylation level of decreasing CpG sites of the three clocks shown on a relative age scale (age divided by the maximum lifespan of species) (left panel). The same is shown for increasing CpG sites (right panel). Standard deviation is indicated by pale coloring around the mean. Source data are provided as a Source Data file.