Fig. 5: Proposed mechanism of the formation of the C6–C5–C6 scaffold by PECPS. | Nature Communications

Fig. 5: Proposed mechanism of the formation of the C6–C5–C6 scaffold by PECPS.

From: Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

Fig. 5

a Decarboxylative condensation of malonyl-CoA with the enzyme-bound 4-hydroxyphenylpropionyl unit. b Formation of the 4-hydroxyphenylpropionyl-β-diketide-CoA intermediate. c Decarboxylative condensation of phenylpropionyl-β-diketide acid nonenzymatically derived from phenylpropionyl-β-diketide-CoA with the enzyme-bound benzoyl unit. d Formation of the C6–C5–C6 scaffold product. e Schematic representation of the proposed mechanism of the formation of the C6–C5–C6 scaffold by PECPS. The entrances to the catalytic cavities are indicated with red arrows.

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