Fig. 5: Scope with respect to cyclic azomethine ylides. | Nature Communications

Fig. 5: Scope with respect to cyclic azomethine ylides.

From: Asymmetric synthesis of N-bridged [3.3.1] ring systems by phosphonium salt/Lewis acid relay catalysis

Fig. 5

Reactions were performed with 1a (0.10 mmol), 2 (0.12 mmol), P10 (0.01 mmol), and Cs2CO3 (0.60 mmol) in Et2O (2.0 mL) at −20 °C for 72 h; then BF3·Et2O (1.0 mmol) was directly added to the reaction mixture which was further stirred at r.t. for 12 h. Isolated yield. The e.e. value was determined by HPLC analysis on a chiral stationary phase.

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