Fig. 5: Enantioconvergent hydrogenation of trisubstituted olefins.
From: Iridium-catalyzed enantioconvergent hydrogenation of trisubstituted olefins
Reaction conditions: 0.1 mmol substrate, 1.0 mol% catalyst, 2 mL DCM, 50 bar H2, 16 h, rt, unless otherwise stated. Isomerically pure starting materials were evaluated on 0.05 mmol scale in 1 mL DCM and conversion was determined by 1H NMR spectroscopy. Enantiomeric excess was determined by SFC or GC analysis, using chiral stationary phases. [a] Catalyst B was used. [b] 100 bar H2. [c] 2.0 mol% catalyst. FG functional group, DCM dichloromethane, rt room temperature, COD 1,5-cyclooctadiene, BArF tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, conv. conversion.
