Fig. 2: Antibacterial activity of the antibiotic/cubosome polytherapy and PMB-loaded cubosome strategies.
From: A polytherapy based approach to combat antimicrobial resistance using cubosomes
a Schematic representation of the FIC synergy checkerboard assay. b Schematic representation of the MIC assay. c–i FIC of antibiotic/cubosome polytherapy and MIC of (w/w %) PMB-loaded cubosomes against isolates of (c–f) A. baumannii, (g) P. aeruginosa, and (h, i) K. pneumoniae in CaMHB medium. Black and red filled bars represent antibiotics and cubosomes (Cub) in FIC, respectively; Black and red pattern bars represent the loaded PMB and the corresponding Cub in MIC, respectively. All data are expressed as the mean ± SD. All experiments were performed in triplicate (n = 3). Mean values and error bars were defined as the mean and SD, respectively. See Source Data for detailed FIC, FICI, and MIC values. MIC minimum inhibitory concentration, FIC fractional inhibitory concentration, Ami amikacin, Azt aztreonam, Dor doripenem, PMB polymyxin B. Source data are provided as a Source Data file.
