Fig. 5: A schematic illustration of the possible mechanism of action against Gram-negative bacteria.
From: A polytherapy based approach to combat antimicrobial resistance using cubosomes
Treatment with (a) PMB-loaded cubosomes and (b) PMB combined with cubosomes. Polytherapy with PMB and cubosomes result in interactions with the bacterial OM in two consecutive ways: PMB initially interacts with the outer leaflet of OM via electrostatic interactions, leading to destabilized areas. Cubosomes then contact with the bilayer, causing further membrane perturbations via a lipid-exchange process.
