Fig. 8: Bayesian regression modeling of glucose tolerance at multiple ages in β-cell specific Insr knockout mice fed two different diets.

Modelled from the same data as Fig. 7. a Tail blood glucose levels (mM) from glucose tolerance tests of control (yellow), βInsr^HET (red), βInsr^KO (blue) LFD-fed female as well as b HFD-fed female and male mice (n = see Fig. 7). All mice received a glucose bolus of 2 g glucose/kg body mass (i.p) except older HFD-fed males, which received only 1 g glucose/kg body mass (i.p). Data were analysed using Bayesian multilevel regression modeling. Bayes factors greater to or equal to 20 for individual time points are shown in pink for comparisons between control and βInsr^HET, and blue for comparisons between control and βInsr^KO. Additional Bayes factors can be found in Supplemental Table S3. Dashed lines indicate individual mice, solid lines and points indicate estimates, and shading indicates 95% credible intervals. Dotted line at 33.3 mM indicates the upper limit of detection of the glucometer and vertical dotted lines rising above this line indicate where measurements were above the limit of detection for an individual mouse. Source data are provided as Source Data file.