Table 1 Unweighted and weighted cohort characteristics (N = 883,416) of unvaccinated individuals, CoronaVac, or Comirnaty recipients.
From: Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong
Unvaccinated | CoronaVac | Comirnaty | Unvaccinated | CoronaVac | Comirnaty | ||
|---|---|---|---|---|---|---|---|
Unweighted | Weighteda | ||||||
n | 547,796 | 182,442 | 153,178 | 536,072 | 124,524 | 96,322 | Maximum weighted SMD |
Age [mean (SD)] | 62.11 (12.85) | 61.58 (11.08) | 56.81 (13.43) | 61.08 (13.33) | 61.08 (11.31) | 61.08 (12.17) | <0.001 |
Sex: male (%) | 229,791 (41.9) | 88,881 (48.7) | 72,586 (47.4) | 242587.9 (44.3) | 80814.1 (44.3) | 67831.5 (44.3) | <0.001 |
Chronic conditions (%) | |||||||
Hypertension | 367,799 (67.1) | 125,314 (68.7) | 93,319 (60.9) | 363621.4 (66.4) | 121104.0 (66.4) | 101688.5 (66.4) | <0.001 |
Diabetes (type 2) | 180,875 (33.0) | 51,312 (28.1) | 36,403 (23.8) | 166524.0 (30.4) | 55471.7 (30.4) | 46570.1 (30.4) | <0.001 |
Severe constipation | 45,405 (8.3) | 16,424 (9.0) | 13,804 (9.0) | 46915.4 (8.6) | 15619.6 (8.6) | 13111.6 (8.6) | <0.001 |
Depression | 34,333 (6.3) | 10,745 (5.9) | 13,310 (8.7) | 36257.6 (6.6) | 12056.4 (6.6) | 10126.4 (6.6) | <0.001 |
Cancer | 31,308 (5.7) | 4671 (2.6) | 4733 (3.1) | 25244.0 (4.6) | 8407.6 (4.6) | 7050.6 (4.6) | <0.001 |
Hypothyroidism | 27,752 (5.1) | 9555 (5.2) | 9508 (6.2) | 29019.7 (5.3) | 9673.0 (5.3) | 8119.2 (5.3) | <0.001 |
Chronic pain | 23,305 (4.3) | 7577 (4.2) | 7845 (5.1) | 24013.3 (4.4) | 8006.3 (4.4) | 6699.9 (4.4) | <0.001 |
Asthma | 18,172 (3.3) | 5119 (2.8) | 7061 (4.6) | 18773.8 (3.4) | 6277.3 (3.4) | 5265.2 (3.4) | <0.001 |
Chronic pulmonary disease | 12,090 (2.2) | 2638 (1.4) | 1663 (1.1) | 10152.9 (1.9) | 3373.7 (1.8) | 2846.7 (1.9) | <0.001 |
Schizophrenia | 10,915 (2.0) | 1634 (0.9) | 1637 (1.1) | 8803.3 (1.6) | 2930.7 (1.6) | 2463.7 (1.6) | <0.001 |
Rheumatoid arthritis | 7654 (1.4) | 1582 (0.9) | 1663 (1.1) | 6783.9 (1.2) | 2257.3 (1.2) | 1883.2 (1.2) | <0.001 |
Peptic ulcer disease | 6662 (1.2) | 2224 (1.2) | 1583 (1.0) | 6502.3 (1.2) | 2162.0 (1.2) | 1810.1 (1.2) | <0.001 |
Alcohol misuse | 4535 (0.8) | 1356 (0.7) | 1278 (0.8) | 4441.6 (0.8) | 1468.2 (0.8) | 1242.3 (0.8) | <0.001 |
Cirrhosis | 3294 (0.6) | 544 (0.3) | 433 (0.3) | 2634.9 (0.5) | 876.7 (0.5) | 746.0 (0.5) | <0.001 |
Parkinson’s disease | 3182 (0.6) | 409 (0.2) | 336 (0.2) | 2419.1 (0.4) | 811.4 (0.4) | 685.1 (0.4) | <0.001 |
Dementia | 3030 (0.6) | 299 (0.2) | 204 (0.1) | 2184.8 (0.4) | 734.9 (0.4) | 607.3 (0.4) | 0.001 |
Psoriasis | 2524 (0.5) | 721 (0.4) | 814 (0.5) | 2513.0 (0.5) | 836.6 (0.5) | 705.5 (0.5) | <0.001 |
Irritable bowel syndrome | 1710 (0.3) | 621 (0.3) | 823 (0.5) | 1960.3 (0.4) | 652.3 (0.4) | 545.5 (0.4) | <0.001 |
Inflammatory bowel disease | 1548 (0.3) | 360 (0.2) | 595 (0.4) | 1584.6 (0.3) | 514.3 (0.3) | 427.3 (0.3) | 0.002 |
Peripheral vascular disease | 93 (0.0) | 9 (0.0) | 9 (0.0) | 91.5 (0.0) | 8.7 (0.0) | 13.9 (0.0) | 0.012 |
Multimorbidity statusb (%) | 0.012 | ||||||
One condition | 344,866 (63.0) | 128,890 (70.6) | 114,311 (74.6) | 363464.1 (66.4) | 121971.7 (66.9) | 102332.2 (66.8) | – |
Two conditions | 168,166 (30.7) | 46,844 (25.7) | 34,071 (22.2) | 155986.2 (28.5) | 51013.4 (28.0) | 42906.3 (28.0) | – |
Three conditions | 28,767 (5.3) | 5893 (3.2) | 4224 (2.8) | 23974.7 (4.4) | 7938.7 (4.4) | 6712.3 (4.4) | – |
Four or more conditions | 5997 (1.1) | 815 (0.4) | 572 (0.4) | 4371.0 (0.8) | 1518.2 (0.8) | 1227.3 (0.8) | – |
Adverse events of special interestb (%) | |||||||
Cardiovascular system | 759 (0.1) | 160 (0.1) | 106 (0.1) | 737.8 (0.1) | 158.1 (0.1) | 118.0 (0.1) | – |
Circulatory system | 689 (0.1) | 135 (0.1) | 113 (0.1) | 664.4 (0.1) | 131.6 (0.1) | 134.3 (0.1) | – |
Hepato-renal system | 513 (0.1) | 148 (0.1) | 86 (0.1) | 508.3 (0.1) | 147.9 (0.1) | 85.7 (0.1) | – |
Auto-immune diseases | 229 (0.0) | 40 (0.0) | 55 (0.0) | 233.5 (0.0) | 41.3 (0.0) | 50.6 (0.0) | – |
Respiratory system | 154 (0.0) | 18 (0.0) | 10 (0.0) | 140.9 (0.0) | 17.9 (0.0) | 12.9 (0.0) | – |
Other system | 113 (0.0) | 42 (0.0) | 43 (0.0) | 105.9 (0.0) | 43.3 (0.0) | 33.7 (0.0) | – |
Nerves and central nervous system | 63 (0.0) | 14 (0.0) | 16 (0.0) | 59.5 (0.0) | 13.6 (0.0) | 16.6 (0.0) | – |
Skin, bone, and joints system | 2 (0.0) | 1 (0.0) | 4 (0.0) | 1.7 (0.0) | 1.1 (0.0) | 2.9 (0.0) | – |
