Fig. 1: Classification of the target protein population.
From: Coding and regulatory variants are associated with serum protein levels and disease
The pie chart shows the relative distribution (percentage) of the different protein classes targeted by the present proteomics platform (4137 unique proteins), with secreted proteins (38.4%) and single-pass transmembrane (SPTM) receptors (32.2%) dominating the target protein population. Protein classes were manually curated based on information from the SecTrans, Gene Ontology (GO), and Swiss-Prot databases, and were composed of secreted proteins (e.g., cytokines, adipokines, hormones, chemokines, and growth factors), SPTM receptors (e.g., tyrosine and serine/threonine kinase receptors), multi-pass transmembrane (MPTM) receptors (e.g., GPCR, ion channels, transporters), enzymes (intracellular), kinases, nuclear hormone receptors (NH receptors), structural molecules, transcriptional regulators and signal transducers.
