Fig. 3: Pleiotropy of rs2251219 affects many proteins and disease traits.
From: Coding and regulatory variants are associated with serum protein levels and disease
The Circos plot highlights the effect of the variant rs2251219 (Supplementary Data 1 and 2) on 13 proteins acting in cis or trans and sharing genetics with various diseases of different etiologies. Only study-wide significant (P < 1.92 × 10−10, two-sided) genotype-to-protein associations (linear regression) are shown. Lines going from rs2251219 show links to genomic locations of the protein-encoding genes associated with the variant while numbers refer to chromosomes. The arrow points to disease-related traits that have previously been linked to rs2251219.
