Fig. 1: Group differences for PD-VH (patients with hallucinations) vs. PD-noVH (without hallucinations). | Nature Communications

Fig. 1: Group differences for PD-VH (patients with hallucinations) vs. PD-noVH (without hallucinations).

From: Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Fig. 1

a The figure is a visual summary of the results for the multivariate between subjects (VH/noVH) ANCOVA, using age, gender and TIV as covariates. Shown are regions whereby PD-VH had decreased cortical thickness (right) and surface area (left). Widespread decreased thickness was found in PD-VH; the regions with the greatest effect size were occipitotemporal (occipitotemporal and occipital sulci, inf. temporal gyrus), parietal (precuneus, intraparietal sulcus) and frontal (superior and middle frontal gyri, inferior frontal gyrus) regions. Surface area was reduced in PD-VH in the right occipitotemporal gyrus/medial occipital cortex. b The figure is a visual summary of the results for the multivariate between subjects (VH/noVH) ANCOVA, using age, gender, TIV, LED, disease onset, UPDRS-III and MMSE as covariates for the replication cohort (N = 146, NPI subsample) (for details see 2.3 and S4). Regions are colour coded by effect size (details in S3). Results were corrected for multiple comparisons (FDR) and pairwise comparisons (Bonferroni) (see “Methods” section). Individual statistical values for each region are provided in the Supplemental Information S3 in tables, one for each morphometric.

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