Fig. 3: Transmission bottleneck size and transmissions of intra-host variants in the outbreak.

a Estimated bottleneck size in donor-recipient transmission pairs (n = 29) was calculated using the exact beta-binomial method. Bars show mean and 95%CI, calculated using the likelihood ratio test. b Minor iSNVs transmission resulted in the diversity of viral population. The pie charts show the frequency of iSNVs. Arrows show the direction of transmission for those pairs of cases for which this is known with high confidence.